Tuesday, January 29, 2013

Community Resource Fair Draws Hundreds of Arlington Families ...

In one morning, Danielle Whetstone browsed low-cost childcare options, chatted with employment agencies, and researched health and wellness programs.

The Arlington mother of two attended the Community Resource Fair on Saturday to learn more about activities and services available in the community.

?I love this,? said Whetstone, who recently completed a degree in social work at the University of Texas at Arlington. ?It?s helpful to have all of these programs under one roof, rather than us having to go out and try to find everything on our own.?

The second annual event, sponsored by Arlington Independent School District, aimed to make Arlington families aware of available community services. Representatives from more than 80 organizations from across North Texas ? including Head Start, Easter Seals, JPS Health and United Way ? were on hand to answer questions and provide information.

Electra Kitchin, AISD coordinator for dropout prevention, said families seek assistance for a variety of reasons, including job loss or financial woes, health problems and special education need.

Help is available, but navigating various aid agencies can be difficult for time-strapped families, said Antrice Newsome, AISD special education coordinator. Schools can help lessen that burden.

?We want parents to know we are looking at the needs of the entire family,? Newsome said. ?We look at the whole child and what they need to be successful.?

Susan Diaz, who attended the fair with her 9-year-old son, Daniel, said she was pleased to learn about the educational assistance available to students and families.

?I was not familiar with most of these organizations,? Diaz said. ?It?s good to know where to turn for help.?

As a working mother and college student, Whetstone said she has relied on organizations such as the YWCA and Head Start to help her children.

?I could not have done everything without the help of the community,? said Whetstone, who attended with her daughters, Zahria, 10, and Trinitee, 9. ?I would love to see more of these fairs and community outreach.?

articles_aisd_012913

Source: http://myarlingtontx.com/2013/01/29/community-resource-fair-draws-hundreds-of-arlington-families/

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Monday, January 28, 2013

France: Mali military enters town of Timbuktu

SEVARE, Mali (AP) ? Malian soldiers entered the city of Timbuktu on Monday after al-Qaida-linked militants fled into the desert having set ablaze a library that held thousands of ancient manuscripts ablaze.

French Col. Thierry Burkhard, the chief military spokesman in Paris, said that there had been no combat with the Islamists who have ruled Timbuktu for nearly 10 months, but that the forces did not yet control the town as of Monday afternoon.

Burkhard said French paratroopers landed north of the city as ground forces headed up from the south.

"The helicopters have been decisive," he said, describing how they aided the ground forces who came from the south as French paratroopers landed north of the city.

News of their arrival came just hours after Timbuktu's mayor confirmed that the fleeing Islamists had in earlier days torched ancient manuscripts in Timbuktu, long revered as a center of Islamic learning.

The militants had occupied Timbuktu for almost 10 months, imposing the strict Islamic version of Shariah, or religious law, across northern Mali while carrying out amputations and public executions.

"In the heart of people from northern Mali, it's a relief ? freedom finally," said Cheick Sormoye, a Timbuktu resident who fled to Bamako, the capital.

The French said Mali's weak military must finish the job of securing Timbuktu. But they have generally fared poorly in combat, often retreating in panic in the face of well-armed and battle-hardened Islamists.

The French-led military operation against the Islamists, who seized the northern half of Mali last year, began 17 days ago when the insurgents encroached further toward the south.

It has scored several successes, but hard questions remain about how the Mali government will hold the cities that have been wrested from the Islamists, and whether there is the will and the ability to chase them into the Sahara which is home to many of these desert fighters.

On Saturday, French forces secured key installations in the northeastern town of Gao. Then overnight Sunday troops secured the Timbuktu airport without firing a shot.

Ground forces backed by French paratroopers and helicopters took control of Timbuktu's airport and the roads leading to the town in an overnight operation, a French military official said Monday.

"There was an operation on Timbuktu last night that allowed us to control access to the town," Col. Burkhard said Monday. "It's up to Malian forces to retake the town."

The mayor of Timbuktu said Monday that the Islamists had torched his office as well as the Ahmed Baba institute ? a library rich with historical documents ? in an act of retaliation before they fled late last week from the city of mud-walled buildings.

"It's truly alarming that this has happened," Mayor Ousmane Halle told The Associated Press by telephone from Bamako. "They torched all the important ancient manuscripts. The ancient books of geography and science. It is the history of Timbuktu, of its people."

He said he didn't have further details as communications to the city have been cut off.

"UNESCO is very concerned about the reports coming out of Timbuktu as to damage on cultural heritage there," said Sue Williams, UNESCO chief spokesperson, on the phone from Paris.

"We're following the situation very closely, and we are in constant contact with the Malian and French authorities on the ground."

Timbuktu, long a hub of Islamic learning, has been home to some 20,000 manuscripts, some dating back as far as the 12th century. It was not immediately known how many of the irreplaceable manuscripts had been destroyed.

Owners have succeeded in removing some of the manuscripts from Timbuktu to save them, while others have been carefully hidden away from the Islamists who seized Timbuktu, Gao and Kidal in the wake of a coup last March.

The Islamists, though, still maintain control of the provincial capital of Kidal further north and are believed to have a complex system of desert bases including self-constructed caves to which they can escape, only to launch attacks at a later date.

The AP reported last month that they have used bulldozers, earth movers and Caterpillar machines left behind by fleeing construction crews to dig what residents and local officials describe as an elaborate network of tunnels, trenches, shafts and ramparts.

Timbuktu, which lies on an ancient caravan route, has entranced travelers for centuries. During their rule on Timbuktu, the militants systematically destroyed UNESCO World Heritage sites.

A spokesman for the al-Qaida-linked militants has said that the ancient tombs of Sufi saints were destroyed because they contravened Islam, encouraging Muslims to venerate saints instead of God.

Among the tombs they destroyed is that of Sidi Mahmoudou, a saint who died in 955, according to the UNESCO website.

The destructions recall tactics used by the Taliban in 2001 when they dynamited a pair of giant Buddhas carved into a mountain in Bamiyan province. Around the same time, the Taliban also rampaged through the national museum, smashing any art depicting the human form, considered idolatrous under their hardline interpretation of Islam. In all, they destroyed about 2,500 statues.

The al-Qaida-linked militants had forced women to wear veils or else face public whippings and people were also lashed for possessing cigarettes. A couple accused of adultery was stoned to death in Kidal, and one man convicted of murder was executed in public in Timbuktu.

The harsh conditions forced many of the town's 50,000 residents to flee south.

Nana Toure, a native of Timbuktu now living in the capital, said she is delighted to hear that the French have arrived but worried how long the Malian soldiers could hold the town without help.

"Frankly, if they secure the city today, I am ready to return immediately to Timbuktu," she said. "French troops must not leave us alone then because those (Islamists) who fled may come back and cause problem to us. French troops have to stay a bit to stabilize the place."

___

Hinnant reported from Paris. Associated Press writers Carley Petesch in Johannesburg, Thomas Adamson in Paris, and Rukmini Callimachi in Sevare, Mali contributed to this report.

Source: http://news.yahoo.com/france-mali-military-enters-town-timbuktu-174145790.html

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Sunday, January 27, 2013

Murray beats Federer, reaches Australian final

Britain's Andy Murray reacts during his semifinal match against Switzerland's Roger Federer at the Australian Open tennis championship in Melbourne, Australia, Friday, Jan. 25, 2013. (AP Photo/Dita Alangkara)

Britain's Andy Murray reacts during his semifinal match against Switzerland's Roger Federer at the Australian Open tennis championship in Melbourne, Australia, Friday, Jan. 25, 2013. (AP Photo/Dita Alangkara)

Switzerland's Roger Federer reacts after winning the second set of his men's semifinal against Britain's Andy Murray at the Australian Open tennis championship in Melbourne, Australia, Friday, Jan. 25, 2013. (AP Photo/Andy Wong)

Britain's Andy Murray gestures for a video replay of a line call during his men's semifinal against Switzerland's Roger Federer at the Australian Open tennis championship in Melbourne, Australia, Friday, Jan. 25, 2013. (AP Photo/Andrew Brownbill)

MELBOURNE, Australia (AP) ? Andy Murray has beaten Roger Federer for the first time in a Grand Slam event to advance to the Australian Open final against top-ranked Novak Djokovic.

Murray, who became the first British man to win a major in 76 years when he beat Djokovic in last year's U.S. Open final, missed a chance to serve for the match in the fourth set before beating Federer 6-4, 6-7 (5), 6-3, 6-7 (2), 6-2 in a tense semifinal Friday.

The No. 3-ranked Murray, who lost Australian finals in 2010 and 2011, will be playing his third consecutive major final when he takes on two-time defending champion Djokovic on Sunday.

Murray lost the Wimbledon final to Federer ? their third meeting in a major ? before his career breakthrough in New York.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-01-25-TEN-Australian-Open/id-8e7a6bcf9eee4ef296e2cad317f54e51

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Friday, January 25, 2013

Right target, but missing the bulls-eye for Alzheimer's

Jan. 23, 2013 ? Alzheimer's disease is the most common cause of late-life dementia. The disorder is thought to be caused by a protein known as the amyloid-beta protein, or Abeta, which clumps together in the brain, forming plaques that are thought to destroy neurons. This destruction starts early, too, and can presage clinical signs of the disease by up to 20 years.

For decades now, researchers have been trying, with limited success, to develop drugs that prevent this clumping. Such drugs require a "target" -- a structure they can bind to, thereby preventing the toxic actions of Abeta.

Now, a new study out of UCLA suggests that while researchers may have the right target in Abeta, they may be missing the bull's-eye. Reporting in the Jan. 23 issue of the Journal of Molecular Biology, UCLA neurology professor David Teplow and colleagues focused on a particular segment of a toxic form of Abeta and discovered a unique hairpin-like structure that facilitates clumping.

"Every 68 seconds, someone in this country is diagnosed with Alzheimer's," said Teplow, the study's senior author and principal investigator of the NIH-sponsored Alzheimer's Disease Research Center at UCLA. "Alzheimer's disease is the only one of the top 10 causes of death in America that cannot be prevented, cured or even slowed down once it begins. Most of the drugs that have been developed have either failed or only provide modest improvement of the symptoms. So finding a better pathway for these potential therapeutics is critical."

The Abeta protein is composed of a sequence of amino acids, much like "a pearl necklace composed of 20 different combinations of different colors of pearl," Teplow said. One form of Abeta, Abeta40, has 40 amino acids, while a second form, Abeta42, has two extra amino acids at one end. Abeta42 has long been thought to be the toxic form of Abeta, but until now, no one has understood how the simple addition of two amino acids made it so much more toxic then Abeta40.

In his lab, Teplow and his colleagues used computer simulations in which they looked at the structure of the Abeta proteins in a virtual world. The researchers first created a virtual Abeta peptide that only contained the last 12 amino acids of the entire 42-amino-acid-long Abeta42 protein. Then, said Teplow, "we just let the molecule move around in a virtual world, letting the laws of physics determine how each atom of the peptide was attracted to or repulsed by other atoms."

By taking thousands of snapshots of the various molecular structures the peptides created, the researchers determined which structures formed more frequently than others. From those, they then physically created mutant Abeta peptides using chemical synthesis.

"We studied these mutant peptides and found that the structure that made Abeta42 Abeta42 was a hairpin-like turn at the very end of the peptide of the whole Abeta protein," Teplow said.

The hairpin turn structure was not previously known in the detail revealed by the researchers, "so we feel our experiments were novel," he said. "Our lab is the first to show that it is this specific turn that accounts for the special ability of Abeta42 to aggregate into clumps that we think kills neurons. Abeta40, the Abeta protein with two less amino acids at the end of the protein, did not do the same thing."

Hopefully, the work of the Teplow laboratory presents what may the most relevant target yet for the development of drugs to fight Alzheimer's disease, the researchers said.

Other authors on the study included Robin Roychaudhuri, Mingfeng Yang, Atul Deshpande, Gregory M. Cole and Sally Frautschy, all of UCLA, and Aleksey Lomakin and George B. Benedek of the Massachusetts Institute of Technology.

Funding for the study was provided by grants from the State of California Alzheimer's Disease Research Fund, a UCLA Faculty Research Grant, the National Institutes of Health (AG027818, NS038328) and the James Easton Consortium for Alzheimer's Drug Discovery and Biomarkers.

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Story Source:

The above story is reprinted from materials provided by University of California, Los Angeles (UCLA), Health Sciences.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Robin Roychaudhuri, Mingfeng Yang, Atul Deshpande, Gregory M. Cole, Sally Frautschy, Aleksey Lomakin, George B. Benedek, David B. Teplow. C-Terminal Turn Stability Determines Assembly Differences between A?40 and A?42. Journal of Molecular Biology, 2013; 425 (2): 292 DOI: 10.1016/j.jmb.2012.11.006

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/xGA4EgL4b6k/130123221409.htm

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Thursday, January 24, 2013

Electric BMW ActiveE Buyers are Varied - Automotive Digest

Electric BMW ActiveE Buyers are Varied

bmw_activee2a

Green Car Reports - January 22, 2013

The writer set out to find out which cars were being traded in for the new elec?tric BMW ActivE, and the results of his ven?ture proved rather interesting.

Which vehi?cles were traded in for the elec?tric BMW?

Of the more than 50 dri?vers who responded?some say?ing what car the ActiveE had sup?planted, even if they didn?t actu?ally trade it in?the list var?ied a?lot.

Many ActiveE dri?vers came from the Mini E test, and had effec?tively swapped their elec?tric Mini Cooper for the elec?tric BMW, which is based on the 1-Series two-door sedan.

Beyond the Mini E, though, there were a num?ber of sedans, even a wagon or two, from Euro?pean brands (Audi, BMW, Saab, Volvo).

There was one Lin?coln LS, the early-2000s attempt by Ford?s lux?ury brand to pro?duce a mid-size lux?ury sport sedan. There was one Jeep Grand Chero?kee.

There were a few Toy?ota Priuses, a Honda Civic Hybrid (for the HOV-lane sticker, its owner can?didly admit?ted), a Mazda Miata, and a Sub?aru Out?back Sport. There was even a motorcycle.

?

?

Source: http://automotivedigest.com/2013/01/electric-bmw-activee-buyers-are-varied/

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Deep freeze slides toward the northeast

The frozen ice covered pair of gloves belonging to a Chicago firefighter stand on a railing behind him in single digit temperatures during a five-alarm blaze in a warehouse on the city's South Side, Bridgeport neighborhood rages Wednesday, Jan. 23, 2013, in Chicago. (AP Photo/Charles Rex Arbogast)

The frozen ice covered pair of gloves belonging to a Chicago firefighter stand on a railing behind him in single digit temperatures during a five-alarm blaze in a warehouse on the city's South Side, Bridgeport neighborhood rages Wednesday, Jan. 23, 2013, in Chicago. (AP Photo/Charles Rex Arbogast)

Icicles form on a fire hose from single digit temperatures as Chicago firefighters battle a five-alarm blaze in a warehouse on the city's South Side, Bridgeport neighborhood Wednesday, Jan. 23, 2013, in Chicago. (AP Photo/Charles Rex Arbogast)

Chicago firefighters battle a five-alarm blaze in single digit temperatures at a warehouse on the city's South Side, Bridgeport neighborhood Wednesday, Jan. 23, 2013, in Chicago. (AP Photo/Charles Rex Arbogast)

A flock of geese huddles to stay warm on a slab of ice enveloped by steam on the Rock River in Watertown, Wis. as arctic air pushes through the Upper Midwest on Tuesday, Jan. 22, 2013. The upper Midwest region is grappling with another day of extreme cold. (AP Photo/Watertown Daily Times, Samantha Christian)

Ice crystals form frost on the window of a home in Medina, Minn. as the area experiences subzero temperatures on Monday, Jan. 21, 2013. (AP Photo/The Star Tribune, Richard Sennott)

(AP) ? The Upper Midwest remained locked in a deep freeze Wednesday as the bitter temperatures crept eastward where at least one mountain resort warned it was too cold even to ski.

Overnight, ice-covered Chicago firefighters spent hours fighting a massive fire at a warehouse on the city's South Side, hindered by the single digit chill.

The cold snap arrived Saturday night as waves of Arctic air swept south from Canada, pushing temperatures to dangerous lows and leaving a section of the country well-versed in winter's pains reeling. The National Weather Service said states from Ohio through to the far northeast of Maine could expect to be slammed by that Arctic blast on Wednesday.

The numbers so far are chilling in themselves: 35 below at Crane Lake, Minn., on Tuesday; Embarrass, Minn., at 36 below on Monday; and Babbitt, Minn., at 29 below on Sunday, according to the National Weather Service.

The weather service issued a wind chill warning for Wednesday in the far north of Maine. In Presque Isle and Caribou, temperatures are not expected to rise above 7 below. And the wind chill could make it feel more like 40 below. Vermont was similarly afflicted, with wind chill advisories and highs peaking in the single digits. Forecasters said Boston and New York City could expect temperatures in the double digits, but that the wind chill would make it feel 5 below. And in mid-Massachusetts, high winds up to 30 mph in Worcester will add to the weather misery.

At least one ski resort in New Hampshire was planning to close Wednesday and Thursday because of the extraordinary cold. Wildcat Mountain in the White Mountains region said it was expecting temperatures in the negative double digits and a wind chill of 48 degrees below zero ? conditions that would not be safe for guests or employees on the slopes.

Late Tuesday, some 170 Chicago firefighters ? approximately one third of the city's fire department ? turned out in frigid temperatures to battle a blaze at a warehouse on the South Side. Officials said the fire prompted the department's biggest response in recent years, according to The Chicago Sun-Times. Despite the scale of the fire, firefighters' soaked jackets and hats froze, and icicles formed and dangled from hoses and hydrants.

Authorities said exposure has played a role in at least four deaths.

On Sunday, a 70-year-old man was found frozen in his unheated home in Des Plaines, Ill. And in Green Bay, Wis., a 38-year-old man was found dead outside his home Monday morning. Authorities in both cases said the victims died of hypothermia and cold exposure, with alcohol a possible contributing factor.

A 77-year-old Illinois woman also was found dead near her car in southwestern Wisconsin on Saturday night, and a 61-year-old Minnesota man was pronounced dead at a hospital after he was found in a storage building Saturday morning.

The bitter conditions were expected to persist into the weekend in the Midwest through the eastern half of the U.S., said Shawn DeVinny, a National Weather Service meteorologist in suburban Minneapolis.

Ariana Laffey, a 30-year-old homeless woman, kept warm with a blanket, three pairs of pants and six shirts as she sat on a milk crate begging near Chicago's Willis Tower on Tuesday morning. She said she and her husband spent the night under a bridge, bundled up under a half-dozen blankets.

"We're just trying to make enough to get a warm room to sleep in tonight," Laffey said.

___

Associated Press writers Doug Glass in Minneapolis, Don Babwin and Tammy Webber in Chicago, Jeff Karoub in Detroit, Dirk Lammers in Sioux Falls, S.D., and Dinesh Ramde and Gretchen Ehlke in Milwaukee contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-01-23-Deep%20Freeze/id-e90ea740d3ca4b2f896c16c111348434

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Wednesday, January 9, 2013

Choices For Apple's Next Retail Chief - Business Insider

Apple has been pretty hush hush about its search for a new SVP of retail following the unexpected departure of retail boss John Browett.

As John Paczkowski of AllThingsD reports, Apple can't afford to make another hiring mistake. So for the last several weeks, Paczkowski has been poking around to find ideal candidates.?

He found three from inside Apple who would be a good fit for the position:

  • Steve Cano, Apple's manager of retail stores
  • Bob Bridger, Apple VP for Retail Real Estate and Development
  • Jeremy McDougal, Apple VP of Retail

His sources are divided over who would be best suited to lead Apple's retail operations.?One says McDougal would be best, considering that he already has the VP of Retail title. But another says Cano would be best because he's the most well-rounded out of the three and understands Apple's retail store culture.

Paczkowski also named five candidates from outside of Apple that Apple would be lucky to hire away, given their experience working for global consumer brands:

  • Angela Ahrendts, CEO, Burberry
  • Victor Luis, President, International Group at Coach
  • Jeanne Jackson, President, Director to Consumer at Nike
  • John Culver, President, Starbucks Coffee China and Asia Pacific
  • Paul Gainer, Executive Vice President, Global Disney Store

However, it would be a hard sell to get these people to leave those powerful positions and join Apple because, as one of?Paczkowski's source said "Apple is not a true retailer."

For now, the retail team reports directly to Apple CEO Tim Cook and Cook is expected to take his time to find a replacement.?

Source: http://www.businessinsider.com/choices-for-apples-next-retail-chief-2013-1

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Would equity investing (stocks & mutual funds) protect you against ...

Yes. The entire definition of inflation is that the price of things go up (Well, actually, that's not really the definition, but that's what most people think the definition is). So if you buy almost *anything* -- stocks, gold, real estate, petrified wood, bubble gum, toothpaste, pretty much anything other than fixed rate bonds -- then in a period of inflation, the price of that thing will go up at roughly the inflation rate.

Of course, not everything inflates at the same rate -- some individual stocks might go up more than the inflation rate while others may go up less than the inflation rate, or even decline. But as long as you're diversified across many different stocks, stocks are as good a thing to own in a period of inflation as anything else.


Last edited by doubled; 01-07-2013 at 03:13 PM.

Source: http://boards.straightdope.com/sdmb/showthread.php?t=678082

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One Direction 'Kiss You'... And Each Other In Latest Video

The guys promised MTV News 'pure stupidity' in their latest video, and they definitely followed through.
By Jocelyn Vena


Niall Horan and Liam Payne in One Direction's "Kiss You" video
Photo: Columbia Records

Source: http://www.mtv.com/news/articles/1699777/one-direction-kiss-you-music-video.jhtml

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